Twelve new compounds from Ligularia melanothyrsa; isolation of melanothyrsins A–E,normelanothyrsin A,and other eremophilane sesquiterpenoids |
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| Authors: | Yoshinori Saito Mayu Ichihara Yasuko Okamoto Xun Gong Chiaki Kuroda Motoo Tori |
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| Institution: | 1. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;2. Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China;3. Department of Chemistry and Research Center for Smart Molecules, Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan |
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| Abstract: | Twelve new compounds, namely, five melanothyrsins A–E (1α-angeloyloxyeremophilenolides), normelanothyrsin A (1α-angeloyloxynoreremophilenone), and six other eremophilane-type compounds, have been isolated from Ligularia melanothyrsa Hand.-Mazz. (Asteraceae), collected in the Sichuan Province of China. Six of the compounds have a 1α-angeloyloxy moiety, while the other six have no functional group at the C-1 position. The absolute configuration was also determined using CD spectra. This is the first chemical study of compounds isolated from this species. |
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| Keywords: | Asteraceae Ligularia melanothyrsa Sesquiterpenoid Eremophilanolide Melanothyrsin |
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