Iriomoteolide-13a,a cytotoxic 22-membered macrolide from a marine dinoflagellate Amphidinium species |
| |
| Authors: | Mai Akakabe Keiko Kumagai Masayuki Tsuda Yuko Konishi Akira Tominaga Masashi Tsuda Eri Fukushi Jun Kawabata |
| |
| Institution: | 1. Science Research Center, Kochi University, Kochi 783-8505, Japan;2. Graduate School of Kuroshio Science and Kochi Medical School, Kochi University, Kochi 783-8505, Japan;3. Center for Advanced Marine Core Research, Kochi University, Kochi 783-8502, Japan;4. Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan |
| |
| Abstract: | Iriomoteolide-13a (1) has been isolated from a benthic dinoflagellate Amphidinium sp. (strain KCA09053) as a new 22-membered macrolide containing one hexahydrofuro3,2-b]furan ring, one tetrahydropyran ring, two tetrahydrofuran rings, three one-carbon branches, and three hydroxyl groups including two hemiketals. The structure of 1 was assigned on the basis of a detailed 2D NMR analysis. Compound 1 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa cells (IC50: 0.5 μg/mL). |
| |
| Keywords: | 22-Membered macrolide Dinoflagellate Amphidinium Cytotoxic activity Hexahydrofuro[3 2-b]furan |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
