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Sustainable,mild and efficient p-methoxybenzyl ether deprotections utilizing catalytic DDQ
Authors:Katie Walsh  Helen F. Sneddon  Christopher J. Moody
Affiliation:1. School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK;2. Green Chemistry Performance Unit, GlaxoSmithKline R&D Ltd, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK
Abstract:A procedure for the selective deprotection of p-methoxybenzyl ethers using catalytic amounts of DDQ and of sodium nitrite, with oxygen as the terminal oxidant, is reported.
Keywords:Deprotection   Oxidation   Quinone
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