New prenylated indole alkaloids from fungus Penicillium sp. derived of mangrove soil sample |
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| Authors: | Bin Yang Junde DongXiuping Lin Xuefeng ZhouYanying Zhang Yonghong Liu |
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| Institution: | CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, China |
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| Abstract: | Three diprenylated indole alkaloids, mangrovamides A–C (1–3), featured a bicyclo 2.2.2] diazaoctane core and possessed a novel γ-methyl proline and isoprene derived dimethyl γ-pyrone functionalities hitherto unknown among the family of paraherquamides, were isolated from the fungus Penicillium sp., which was separated from a mangrove soil sample. The structures were elucidated based on NMR, X-ray, and CD methods. The possible biosynthetic pathway of these compounds is proposed. |
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| Keywords: | Penicillium sp Prenylated indole alkaloids Mangrovamides X-ray diffraction Anti-acetylcholinesterase activity |
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