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Pd(PPh3)4-catalyzed direct ortho-fluorination of 2-arylbenzothiazoles with an electrophilic fluoride N-fluorobenzenesulfonimide (NFSI) |
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| Authors: | Qiuping Ding Changqing Ye Shouzhi Pu Banpeng Cao |
| Institution: | 1. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology, Normal University, Nanchang, Jiangxi 330013, PR China;2. Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, PR China |
| Abstract: | An efficient protocol was developed for regio-selective Pd-catalyzed direct ortho-fluorination of 2-arylbenzod]thiazoles using N-fluorobenzenesulfonimide (NFSI) as the F+ source, and l-proline as the crucial promoter. The present method offered a practical route to synthesize valuable fluorinated products, which are of potential importance in the pharmaceutical and agrochemical industries. |
| Keywords: | 2-Arylbenzo[d]thiazole Fluorination N-Fluorobenzenesulfonimide l-Proline |
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