Hyrtimomines,indole alkaloids from Okinawan marine sponges Hyrtios spp. |
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| Authors: | Naonobu Tanaka Rei Momose Azusa Takahashi-Nakaguchi Tohru Gonoi Jane Fromont Jun'ichi Kobayashi |
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| Institution: | 1. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan;2. Medicinal Mycology Research Center, Chiba University, Chiba 260-8763, Japan;3. Western Australian Museum, Locked Bag 49, Welshpool DC, WA 6986, Australia |
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| Abstract: | Six new indole alkaloids, hyrtimomines F–K (1–6), were isolated from Okinawan marine sponges Hyrtios spp. The structures of 1–6 were elucidated on the basis of spectroscopic analysis. Hyrtimomine F (1) is a structurally unique bisindole alkaloid possessing an α-keto-?-caprolactam ring, while hyrtimomine G (2) is a symmetrical bisindole alkaloid. Hyrtimomines H–K (3–6) are indole alkaloids possessing β-carboline skeleton with an imidazolium unit. Antimicrobial activities of hyrtimomines F–K (1–6) were evaluated. |
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| Keywords: | Indole alkaloids Marine sponge Hyrtios spp Hyrtimomines |
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