Highly selective acetoxylation of sulfonamides via using phenyliodine(III) diacetate |
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| Authors: | Sichang Wang Zhangqin Ni Yanjie Wang Yihui Pang Yuanjiang Pan |
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| Affiliation: | 1. Department of Chemistry, Zhejiang University, Hangzhou 310027, China;2. College of Pharmacy, China Pharmaceutical University, Nanjing 211169, China |
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| Abstract: | A highly efficient acetoxylation reaction of N-aryl-arylsulfonamides has been developed, presumably proceeding via the selective functionalization of N-aryl C–H bonds. A stoichiometric amount of PhI(OAc)2 was generally employed as the oxidation reagent, and various para-acetoxylated sulfonamide derivatives had been generated in excellent yields. This chemistry endowed an economic synthesis of valuable acetoxylated sulfonamides through direct C–O bond formation processes. |
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| Keywords: | para-Acetoxylation ortho-Acetoxylation N-Phenylbenzenesulfonamides |
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