A mild and efficient amidation of cyclic ethers catalyzed by rhodium caprylate |
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| Authors: | Ling-Hui Gu Dan-Dan ZhangQing-Rong Qi Ping Yin Ling He |
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| Institution: | Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, PR China |
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| Abstract: | A small quantity of Rh2(O2CC7H15)4 (2.5 mol % to 0.6 mol %) catalyzed the α-amidation of cyclic ethers under mild conditions, 35 °C, in the presence of electron-withdrawing p-chlorobenzenesulfonamide/PhI(OAc)2 as the nitrene source, in CH2Cl2 for 4 h. The corresponding N-substituted amino cyclic ethers were successfully obtained in good yields (up to 87% based on 99% conversion) and compatibility with other oxidant sensitive structures in one-pot reaction. |
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| Keywords: | Amidation of cyclic ethers Rh2(O2CC7H15)4 ρ-Chlorobenzene-sulfonamide PhI(OAc)2 One-pot reaction |
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