Efficient access to fluorinated homoallylic alcohols through an indium promoted fluoroallylation reaction |
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Authors: | Gérald Lemonnier Nathalie Van HijfteMuriel Sebban Thomas PoissonXavier Pannecoucke |
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Institution: | Normandie Univ, COBRA, UMR 6014 et FR 3038, Univ. Rouen, INSA Rouen, CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France |
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Abstract: | Herein, an efficient access to fluorinated homoallylic alcohol is reported. The fluorinated alcohols were obtained in good to excellent yield using indium and halo-fluorinated allylic derivatives. The developed methodology using γ-substituted halo-fluorinated allylic derivatives gave the corresponding α-substituted fluorinated homoallylic alcohol in good yields and good diastereoselectivities up to 86:14. |
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Keywords: | Fluorine Fluoroolefins Allylation reaction Indium |
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