A synthesis of 5-hydroxysedamine using hydroformylation |
| |
| Authors: | Roderick W Bates Nur Filza bte Mohamed Aslam Chi H Tang Oliver Simon |
| |
| Institution: | 1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore;2. Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore 138670, Singapore |
| |
| Abstract: | A synthesis of 5-hydroxysedamine, a Sedum alkaloid, has been completed using N,O-heterocycle chemistry to establish the aminoalcohol structure, hydroformylation to form the piperidine ring and diastereoselective dihydroxylation to introduce the 5-hydroxy group. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
