One-pot,three-component synthesis of highly functionalized pyrimidone derivatives and access to indole fused pyrimidones via palladium-catalyzed intramolecular Heck reaction |
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Authors: | Ming Lei Wan TianWei Li Ping LuYanguang Wang |
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Institution: | Department of Chemistry, Zhejiang University, Hangzhou 310027, China |
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Abstract: | A simple and facile approach to highly functionalized pyrimidone derivatives and indole fused pyrimidones has been developed. The synthesis of substituted pyrimidone derivatives in moderate to good yields involves 4+2] cycloaddition of 1,4-dipoles generated from α,β-unsarurated imines and dimethyl acetylenedicarboxylate (DMAD) with isocyanates as dipolarophiles. Furthermore, the pyrimidones resulted from 2-bromophenyl isocyanate could be transformed into various indole fused pyrimidones via intramolecular palladium-catalyzed Heck reaction under different conditions. |
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Keywords: | Multi-component reactions Pyrimidone derivatives Indole fused pyrimidones [4+2] cycloaddition Intramolecular Heck reaction |
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