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Aza-Michael reaction: selective mono- versus bis-addition under environmentally-friendly conditions |
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| Authors: | Giovanna Bosica Jonathan SpiteriCaroline Borg |
| Affiliation: | Department of Chemistry, University of Malta, Msida MSD 2080, Malta |
| Abstract: | Aza-Michael reactions between primary amines and methyl propenoate have been investigated under environmentally-friendly solventless heterogeneous catalysis in order to obtain the mono- or the bis-adduct. The reaction conditions can be altered so as to maximise the yields of the required product with high selectivity. |
| Keywords: | Aza-Michael reaction Primary amines Mono-addition Bis-addition Solvent-free Acidic alumina |
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