Construction of anti-1,2-diols bearing chiral tertiary alcohol moiety using free hydroxyacetone as aldol donor by imidazole-based prolineamide catalyst |
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| Authors: | Wengang Guo Jianwei Wei Yan Liu Can Li |
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| Institution: | 1. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China;2. Graduate School of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | A direct aldol reaction of free hydroxyacetone and activated ketone has been firstly achieved with a newly developed imidazole-based prolineamide catalyst. The adducts anti-1,2-diols bearing a chiral tertiary alcohol moiety were obtained in high yield (up to 92%) and stereoselectivity (up to 15:1 dr and 90% ee). |
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| Keywords: | Imidazole Organocatalyst Hydroxyacetone Asymmetric Aldol reaction |
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