Preparation of renieramycin left-half model compounds |
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Authors: | Keiyo Nakai Keiji KuboMasashi Yokoya Naoki Saito |
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Affiliation: | Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan |
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Abstract: | Model compounds of the left-half of renieramycins, which are anticancer marine natural products having an α-aminonitrile functionality, were prepared from phenylalanine derivatives. The key step of the transformation is the stereospecific construction of 1,3-cis stereochemistry via an exomethylene intermediate. The stereoselective α-aminonitrile formation under kinetically controlled conditions is also discussed. The initial cytotoxicity profiles are presented. |
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Keywords: | Preparation Marine natural product Isoquinoline Renieramycin Cytotoxicity |
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