Synthesis of novel indolo[2,3-c]quinolinones via Ugi-4CR/palladium-catalyzed arylation |
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| Authors: | Mohammad Ali Rasouli Mohammad Mahdavi Loghman Firoozpour Abbas Shafiee Alireza Foroumadi |
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| Affiliation: | 1. School of Chemistry, University College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran;2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran;3. Drug Design & Development Research Center, Tehran University of Medicinal Sciences, Tehran, Iran |
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| Abstract: | In this letter, an expedient method was developed for the construction of novel indolo[2,3-c]quinolinone derivatives via palladium-catalyzed arylation of Ugi adducts obtained from the reaction of indole-2-carboxylic acid, various aromatic aldehydes, 2-bromoanilines, and isocyanides. The reaction proceeded efficiently with various starting materials to produce the indoloquinolinone scaffolds in good yields. |
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| Keywords: | Indolo[2,3-c]quinolinone Ugi reactions Pd-catalyzed Heterocycles |
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