Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction |
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Authors: | Zhi-Peng Chen Hai-Bo WangYu-Qin Wang Qiu-Hua Zhu Yang Xie Shu-Wen Liu |
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Affiliation: | School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, China |
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Abstract: | Novel proline-catalyzed multicomponent reactions (MCRs) for the synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidines 7 and 9 with different substituted patterns have been developed, which provide rapid access to a library of compounds 7 and 9 in medium to excellent yields, by using N-methyl-α-aryl(alkyl)aminomaleimides, amines, and aldehydes as reactants. The catalyst and the ratio of reactants were found to have significant impact on these reactions, and a reasonable mechanism was also proposed. |
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Keywords: | Multicomponent reaction Proline Pyrrolo[3,4-d]tetrahydropyrimidine Synthesis |
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