| STUDY ON REPRODUCTIVE ENDOCRINOLOGY OF HUMAN PLACENTA (Ⅲ)——HORMONAL REGULATION OF PROGESTERONE PRODUCTION BY TROPHOBLAST TISSUE OF FIRST TRIMESTER |
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| 引用本文： | 施从柱,张致一,庄临之.STUDY ON REPRODUCTIVE ENDOCRINOLOGY OF HUMAN PLACENTA (Ⅲ)——HORMONAL REGULATION OF PROGESTERONE PRODUCTION BY TROPHOBLAST TISSUE OF FIRST TRIMESTER[J].中国科学B辑(英文版),1991(9). |
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| 作者姓名： | 施从柱 张致一 庄临之 |
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| 作者单位： | Laboratory of Reproductive Biology，Institute of Zoology，Academia Sinica，Laboratory of Reproductive Biology，Institute of Zoology，Academia Sinica，Laboratory of Reproductive Biology，Institute of Zoology，Academia Sinica |
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| 基金项目： | Project supported in part by a grant-in-aid from the Rockefeller Foundation, New York. |
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| 摘 要： | The effect of hormones on progesterone secretion by 6-8 week human trophoblast tissue cultured in serum-free medium has been investigated. GnRH at low concentration (10-10-10-8 mol/L) stimulated progesterone secretion, while high dose (10-6-10-5 mol/L) produced inhibitory effect. The progesterone secretion could be significantly decreased by addition of anti-hCG antiserum or monoclonal anti-hCG IgG in a dose- and time-dependent manner. Various concentrations of TRH, PGE2, PGF2α, testosterone and estradiol were found to be ineffective. These data indicate clearly that progesterone production by human trophoblast tissue at early gestation stage is under the modulation of GnRH and hCG.
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