Sperry versus Hebb: Topographic mapping in Isl2/EphA3 mutant mice |
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| Authors: | Dmitry Tsigankov and Alexei A Koulakov |
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| Institution: | 1.Cold Spring Harbor Laboratory,Cold Spring Harbor,USA;2.Max-Planck Institute for Dynamics and Self-Organization,Gottingen,Germany;3.Bernstein Center for Computational Neuroscience,Gottingen,Germany |
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| Abstract: | Background In wild-type mice, axons of retinal ganglion cells establish topographically precise projection to the superior colliculus
of the midbrain. This means that axons of neighboring retinal ganglion cells project to the proximal locations in the target.
The precision of topographic projection is a result of combined effects of molecular labels, such as Eph receptors and ephrins,
and correlated neural activity. In the Isl2/EphA3 mutant mice the expression levels of molecular labels are changed. As a
result the topographic projection is rewired so that the neighborhood relationships between retinal cell axons are disrupted. |
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