Clinical Evaluation of the Cutaneous Phototoxicity of 5,10,15,20-Tetra (m-hydroxyphenyl)chlorin |
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| Authors: | Georges Wagnieres,Christophe Hadjur,Pierre Grosjean,Daniel Braichotte,Jean-Franç ois Savary,Philippe Monnier,Hubert van den,Bergh |
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| Affiliation: | Institute of Environmental Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland;Department of Otolaryngology, Head and Neck Surgery, CHUV Hospital, Lausanne, Switzerland |
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| Abstract: | The cutaneous phototoxic reaction induced by intravenous injection of 5,-10,-15,-20-tetra(m-hydroxyphenyl)chlorin (mTHPC) has been clinically evaluated in patients undergoing photodynamic therapy. These tests were performed on the backs of 23 patients with a solar simulator at various times after drug administration ranging from 5 h to 57 days. The mTHPC doses ranged from 0.1 to 0.3 mg/kg, and the illuminations lasted from 30 s up to 8 min. These tests have shown that the duration of the skin photosensitization induced after a typical therapeutic dose of mTHPC (0.15 mg/kg) is less important than with Photofrin®(2 mg/kg). The level of mTHPC in the skin was also assessed in vivo and at times corresponding to the irradiations using an optical fiber-based spectrofiuorometer. This study indicates that the light-induced fluorescence spectroscopy of mTHPC enables prediction of the degree of photosensitivity of the skin. |
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