首页 | 本学科首页   官方微博 | 高级检索  
     检索      


2-Amino-5,5-bis(hydroxymethyl)-1,3-thiazol-4(5H)-one and its spirodioxane compounds in the Mannich reaction
Authors:S M Ramsh  A G Ivanenko  N L Medvedskiy  D G Lagerev  D B Lazarev  L N Belobrzeckaja Costa
Institution:(1) St. Petersburg State Technical University, St. Petersburg, 198013, Russia;(2) Institute Toxicology, Ministry of Public Health of Russia, St. Petersburg, 193019;(3) Genoa State University, Genoa, Italy
Abstract:It was found that the aminomethylation of 2-amino-5,5-bis(hydroxymethyl)-1,3-thiazol-4(5H)-one and its spiro analogs using primary amines is accompanied by cyclization at the amidine fragment of the molecule with annelation of a tetrahydrotriazine ring. When using secondary amines the aminomethylation occurs at the exocyclic nitrogen atom. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1252–1260, August, 2006.
Keywords:2-amino-5  5-bis(hydroxymethyl)-1  3-thiazol-4(5H)-one  2-′  amino-2-aryl(hetaryl)spiro-[1  3-dioxan-5  5′  (4′  H)-1′    3′  -thiazol]-4′  -ones  5-methyl-and 2-amino-5-ethyl-1  3-thiazol-4(5)-ones  aminomethylation
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号