Studies on AI-77s,microbial products with gastroprotective activity. Structures and the chemical nature of AI-77s |
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Authors: | Yukiji Shimojima Hiroshi Hayashi Tadaaki Ooka Mitsuru Shibukawa Yoichi Iitaka |
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Institution: | Technical Research Laboratory, Asahi Chemical Industry Co Ltd, 2-1, Samejima, Fuji-shi, Shizuoka 416 Japan;Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113 Japan |
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Abstract: | The structures and the chemical nature of a novel gastroprotective substance AI-77-B (1) and its analogues AI-77-C (2), D (3), F (4) and G (5), which are produced by Bacillus pumilus AI-77, are described. The structure of 1 was confirmed to be 6-1(S)-(3(S), 4-dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]amino]-4(S),5(S)-dihydroxy-6-oxo-3(S)-aminohexanoic acid by X-ray in combination with chemical studies and the structures of 2, 3, 4 and 5 were determined by chemical syntheses from 1 and spectral analyses. |
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