Oligonucleotide cross-linking with copper ions. Spectral and quantum chemical study |
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| Authors: | S S Bachurin T G Faleeva M E Kletskii O N Burov O I Askalepova I V Kornienko |
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| Institution: | 1.Rostov State Medical University,Rostov-on-Don,Russia;2.Mechnikov North–West State Medical University,St. Petersburg,Russia;3.Branch no. 2, Head State Center of Forensic and Criminalistic Examinations,Ministry of Defence of the Russian Federation,Rostov-on-Don,Russia;4.Southern Federal University,Rostov-on-Don,Russia;5.Academy of Biology and Biotechnologies,Southern Federal University,Rostov-on-Don,Russia |
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| Abstract: | Copper(II) complexes with synthetic oligonucleotides consisting of repeating adenine–thymine and guanine–cytosine complementary base pairs have been studied by UV spectroscopy and simulated by DFT quantum chemical calculations at the B3LYP/6-311G++(d,p) level of theory with inclusion of solvation (hydration) effects. The obtained data suggest selective interaction of copper(II) ions with guanine–cytosine complementary pairs, followed by DNA cross-linking at those sites. |
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