Diastereotopic derivatives of chiral alkoxyisoindolinones |
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| Authors: | T A Grigoreva A V Garabadzhiu V G Tribulovich |
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| Institution: | 1.St. Petersburg State Institute of Technology (Technical University),St. Petersburg,Russia |
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| Abstract: | A method for synthesis of 2,3-substituted 3-hydroxyisoindolin-1-one acyl derivatives, modified reactivators of tumor suppressor protein p53, was developed; these compounds were synthesized and characterized. It was shown that diastereomeric esters of Boc-N-protected amino acids, unlike esters with a free amino group, can be preparatively isolated by flash chromatography using achiral media. |
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