The alkaloidal profile of cocculus pendulus |
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| Authors: | S. Fazal Hussain Lajber Khan Hélène Guinaudeau John E. Leet Alan J. Freyer Maurice Shamma |
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| Affiliation: | P.C.S.I.R. Laboratories, Peshawar Pakistan;Department of Chemistry, The Pennsylvania State University, University Park, PA 16802 U.S.A. |
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| Abstract: | (+)-Kohatine (5), (+)-kun-amine (7), (+)-norpenduline (11), and (+)-cheratamine (12), are four new bisbenzylisoquinolines obtained from Cocculus pendulus (Forsk) Diels (Menispermaceae). Ten known bisbenzylisoquinolines are also present. All fourteen alkaloids possess the S chirality at C-1'. The biogenetic sequence involves initial condensation of two coclaurine-type units to form a dinner such as 16. Species 16 may in turn lead to dimers 17 or 18 with two diaryl ether linkages. Only dimer 17 may undergo further oxidative coupling to bisbenzylisoquinolines with three diaryl ether bridges. |
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