Mercuric triflate-catalyzed tandem cyclization leading to polycarbocycles |
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Authors: | Imagawa Hiroshi Iyenaga Tomoaki Nishizawa Mugio |
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Affiliation: | Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. |
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Abstract: | [reaction: see text] We developed Hg(OTf)2-catalyzed cyclization of (E)-1,3-dimethoxy-5-(4-methyl-3-nonen-7-ynyl)benzene leading to the formation of (4aS,10aS)-3,4,4a,9,10,10a-hexahydro-5,7-dimethoxy-1,4a-dimethylphenanthrene in 98% yield with up to 100 catalytic turnovers. This is the first mercuric salt-catalyzed biomimetic tandem cyclization. |
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