Synthesis of polysubstituted 3H-pyrimidin-4-ones from cyanoacetamides under Vilsmeier conditions |
| |
| Authors: | Zhiguo ZhangXiao Liu Qian Zhang Qun Liu |
| |
| Institution: | a School of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang 453007, PR China
b Department of Chemistry, Northeast Normal University, Changchun 130024, PR China |
| |
| Abstract: | A facile and efficient approach to a variety of 6-chloro-3,5-disubstituted 3H-pyrimidin-4-ones 2/6 from the readily available cyanoacetamides 1/5 under Vilsmeier conditions was developed, in which the Vilsmeier reagent plays multiple roles and the possible mechanism is discussed. |
| |
| Keywords: | Polysubstituted 3H-pyrimidin-4-ones Vilsmeier reagent Cyclopropanes Ring expansion |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
