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Characterization of lidocaine:hydroxypropyl-β-cyclodextrin inclusion complex |
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| Authors: | Carolina Morales Moraes Priscila Abrami Daniele Riberio de Araujo Angélica F. A. Braga Michelle Georges Issa Humberto G. Ferraz Eneida de Paula Leonardo Fernandes Fraceto |
| Affiliation: | 1. Departamento de Farmácia, Universidade de Sorocaba, Rod. Raposo Tavares, km 92,5 CEP, Sorocaba, SP, 18023-000, Brazil 2. Departamento de Bioquímica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil 3. Departamento de Anestesiologia, F.C. Médicas, UNICAMP, Campinas, SP, Brazil 4. Departamento de Farmácia, F.C. Farmacêuticas, Universidade de S?o Paulo (USP), Sao Paulo, SP, Brazil |
| Abstract: | An inclusion complex was prepared between the local anesthetic lidocaine (LDC) and hydroxypropyl-β-CD (HP-β-CD). The complex was characterized by thermal analysis (differential scanning calorimetry, DSC), UV absorption and high-pressure liquid chromatography (HPLC). DSC results were indicative of complexation, due to the loss of the characteristic endothermic peak of LDC (77 °C). Phase-solubility diagrams allowed the determination of the association constant between LDC and HP-β-CD (35.7 ± 4.7 M−1). The rate of LDC release decreased after complexation and thermodynamic parameters from the HPLC studies (ΔG° = −2.65 kJ/mol) revealed that a stable complex was formed. |
| Keywords: | Lidocaine HP-β -CD HPLC Association constant Thermodynamic parameters |
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