纳米硅酸镁锂-壳聚糖-海藻酸钠复合支架材料的制备与性能

利用真空冷冻干燥技术, 将不同质量的纳米硅酸镁锂(nLMS)与壳聚糖(CA)和海藻酸钠(SA)混合, 制备了纳米硅酸镁锂-壳聚糖-海藻酸钠(nLMS-CS-SA)复合支架材料. 研究了不同质量分数(1%, 2%, 3%, 4%)的nLMS对nLMS-CS-SA复合支架材料的外形、 微观形貌、 溶胀率、 孔隙率、 体外降解性能和生物相容性的影响, 以确定nLMS-CS-SA复合支架材料中最佳nLMS含量. 研究结果显示, nLMS-CS-SA复合支架材料是具备形态可塑性的多孔状固体, 各组材料纵断面呈片层状, 其结构疏松且内部孔隙具有高度连通性; 随着nLMS含量的增加, nLMS-CS-SA复合支架材料的孔隙率呈现先降后升的趋势; 当nLMS的质量分数为3%时, 其溶胀比最小, 体外降解速率最慢; nLMS的添加降低了nLMS-CS-SA复合支架材料的毒性. 因此, nLMS在nLMS-CS-SA复合支架材料中的最佳含量为3%.

Preparation and Properties of Nano Lithium Magnesium Silicate-chitosan-sodium Alginate Composite Scaffold Materials

Using vacuum freeze-drying technology， composite scaffolds were fabricated by mixing different mass fractions of nano-lithium magnesium silicate（nLMS） with chitosan and sodium alginate. Results showed that the composite scaffolds were porous solids possessing morphological plasticity， the longitudinal section of the composite scaffold was lamellar， the structure was loose and the internal pores were highly connected. With the increase of nLMS content， the porosity of the composite scaffold decreased and then increased. When the mass fraction of nLMS solution was 3%， both the swelling ratio and the degradation rate of the composite scaffold were the lowest. Besides， the addition of nLMS reduced the toxicity of the composite scaffold. The optimal mass fraction of nLMS solution to prepare the composite scaffold is 3%.