| Wnt信号通路与干细胞定向分化 |
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| 引用本文： | 谭效忠,黄舒扬,杜德强,孟小倩.Wnt信号通路与干细胞定向分化[J].山东师范大学学报(自然科学版),2008,23(1):137-139. |
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| 作者姓名： | 谭效忠 黄舒扬 杜德强 孟小倩 |
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| 作者单位： | 山东师范大学生命科学学院,250014,济南 |
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| 摘 要： | Wnt信号通路在胚胎发育过程中参与背腹轴的形成、细胞极性的建立以及决定细胞命运.利用干细胞定向分化模型可在体外培养条件下探索Wnt信号通路在哺乳动物早期胚胎发育过程中的分子机理,了解其信号网络对干细胞定向分化中各个事件的调控机制.本文通过综合近期Wnt信号通路的研究,阐述经典Wnt信号通路(Canonical Wnt signaling pathway)在干细胞定向分化中的作用.
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| 关 键 词： | Wnt信号通路 干细胞 分化 |
| 收稿时间： | 2007-08-07 |
| 修稿时间： | 2007年8月7日 |
WNT SIGNALING PATHWAY AND STEM CELL DIFFERENTIATION |
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| Tan Xiaozhong,Huang Shuyang,Du Deqiang,Meng Xiaoqian.WNT SIGNALING PATHWAY AND STEM CELL DIFFERENTIATION[J].Journal of Shandong Normal University(Natural Science),2008,23(1):137-139. |
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| Authors: | Tan Xiaozhong Huang Shuyang Du Deqiang Meng Xiaoqian |
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| Abstract: | Wnt signaling pathway has been indicated to play key roles in the formation of dorsal and ventral axis,the generation of cell polarity and the specification of cell fate in embryonic development.With the establishment of stem cell in vitro model of early mammalian development,we are able to figure out the specific molecular mechanism of Wnt signaling pathway in the regulation of stem cell differentiation.Recent advances in our understanding of Canonical Wnt signaling pathway,detailed in this review,have provided new insights essential for manipulating stem cell differentiation. |
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| Keywords: | Wnt signaling stem cell differentiation |
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