蝴蝶霉素及其类似物的化学合成进展

蝴蝶霉素是一种新型的天然抗生素，由于具有特殊的抗肿瘤活性而引起了人们的关注。然而，由于一些不利因素导致蝴蝶霉素无法直接运用于临床。为了寻找活性更好的药物先导化合物，人们对蝴蝶霉素的结构进行修饰和改造，通过生物方法和化学方法，合成了大量的类似物。本文将从化学合成角度出发，立足蝴蝶霉素及其类似物结构构造的关键步骤，对近年来的合成研究进行综述。

Chemical Synthesis of Rebeccamycin and Its Analogues

Rebeccamycin, as a new natural antibiotics, is of great interest to researchers for its potential antitumor activity. However, it cannot be directly utilized as a drug for some disadvantages by itself. To search for better lead compounds, the structure of rebeccamycin was modified or altered, and large numbers of its analogues have been obtained, via biosynthesis and chemical synthesis. Herein, we will present a review of recent progress in chemical synthesis of rebeccamycin and its analogues.