| Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine |
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| 作者姓名： | Die Cheng Deng Ke Liu Mo Liu Ying Liu Wei Ren Xu Chang Xiao Liu |
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| 作者单位： | a Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of China;b Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, People's Republic of China;c State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, People's Republic of China |
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| 摘 要： | A series of novel derivatives of 4, 5, 6, 7-tetrahydrothieno 3,2-c] pyridine were synthesized and structurally characterized by 1H NMR and MS. Their in vivo anti-platelet aggregation activities were evaluated. A 3D-QSAR was performed using the CoMFA and the CoMSIA. This model provided useful guidelines for novel anti-platelet thienopyridines design.
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| 关 键 词： | 合成 活度评估 P2Y12感受器 3D-QSAR |
Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine |
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| Die Cheng,Deng Ke Liu,Mo Liu,Ying Liu,Wei Ren Xu,Chang Xiao Liu.Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine[J].Chinese Chemical Letters,2008,19(9):1075-1079. |
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| Authors: | Die Cheng Deng Ke Liu Mo Liu Ying Liu Wei Ren Xu Chang Xiao Liu |
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| Institution: | a Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of China;b Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, People's Republic of China;c State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, People's Republic of China |
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| Abstract: | A series of novel derivatives of 4, 5, 6, 7-tetrahydrothieno 3,2-c] pyridine were synthesized and strucmrally characterized by 1H NMR and MS. Their in vivo anti-platelet aggregation activities were evaluated. A 3D-QSAR was performed using the CoMFA and the CoMSIA. This model provided useful guidelines for novel anti-platelet thienopyridines design. |
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| Keywords: | Thienopyfidines Anti-platelet aggregation activities P2Y12 receptors 3D-QSAR |
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