Total synthesis of apratoxin A |
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| Authors: | Doi Takayuki Numajiri Yoshitaka Munakata Asami Takahashi Takashi |
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| Institution: | Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1, Ookayama, Meguro, Tokyo 152-8552, Japan. doit@apc.titech.ac.jp |
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| Abstract: | reaction: see text]. We have achieved a total synthesis of apratoxin A in which thiazoline formation was accomplished from the moCys containing amide 4 using PPh3(O)/Tf2O. Deprotection of the Troc and allyl ester in 17, coupling with tripeptide 3, and deprotection of the allyl ester and the Fmoc, followed by macrolactamization provided apratoxin A (1). |
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