MASS TRANSPORT IN SOLID TUMORS (Ⅰ)──FLUID DYNAMICS |
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摘 要: | A three-porous-medium model for transvascular exchange and extravascular transport of fluid and macromolecules in a spherical solid tumor is developed. The microvasculature, lymphatics, and tissue space are each treated as a porous medium with the flow of blood. lymph, and interstitial fluid obeying Darcy’s law and Starling’s assumption. In this part, the role of interstitial pressure and fluid convection are studited. The analytical soiutions are obtained for foe isolated tumor and the normal-tissue-surrounded tumor respectively. The calculated interstitial pressure profue are consistent with the experimental observation that the elevated interstitial pressure is a major barrier in the penetration of macromolecular drug into tumors. The factors which may reduce the interstitial pressure are analyzed in details.
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收稿时间: | 5 May 1997 |
Mass transport in solid tumors (I)—Fluid dynamics |
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Authors: | Lei Xiaoxiao Wu Wangyi Wen Gongbi Chen Jiaoguo |
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Institution: | (1) Department of Mechanics and Engineering Science, Peking University, 100871 Beijing, P. R. China |
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Abstract: | A three-porous-medium model for transvascular exchange and extravascular transport of fluid and macromolecules in a spherical
solid tumor is developed. The microvasculature, lymphatics, and tissue space are each treated as a porous medium with the
flow of blood, lymph, and interstitial fluid obeying Darcy's law and Starling's assumption. In this part, the role of interstitial
pressure and fluid convection are studied. The analytical solutions are obtained for the isolated tumor and the normal-tissue-surrounded
tumor respectively. The calculated interstitial pressure projue are consistent with the experimental observation that the
elevated interstitial pressure is a major barrier in the penetration of macromolecular drug into tumors. The factors which
may reduce the interstitial pressure are analyzed in details. |
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Keywords: | three-porous-medium model mass transport interstitial pressure fluid exchange physiological barriers in tumors |
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