| An Improved and Convenient Procedure for the Synthesis of Ozagrel |
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| 引用本文： | Chun GUO Xiao Dan LIU Zhen Gang XIE Chu Jun LI. An Improved and Convenient Procedure for the Synthesis of Ozagrel[J]. 中国化学快报, 2006, 17(2): 180-182 |
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| 作者姓名： | Chun GUO Xiao Dan LIU Zhen Gang XIE Chu Jun LI |
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| 作者单位： | Chun GUO，Xiao Dan LIU，Zhen Gang XIE，Chu Jun LI School of Pharmaceutical Engineering，Shenyang Pharmaceutical University，Shenyang 110016 |
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| 摘 要： | Ozagrel 1 is a 1-alkylimidazole derivative that acts as a selective inhibitor ofthromboxane A2 (TXA2) with an IC50 of 11mol/L. The beneficial effects of TXA2inhibition by ozagrel include improved motor coordination after experimental stroke, andantihypert…
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| 关 键 词： | 合成 1 1-羧基二咪唑 奥扎格雷 水解作用 抗血栓药 |
| 收稿时间： | 2005-06-20 |
An Improved and Convenient Procedure for the Synthesis of Ozagrel |
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| Chun GUO,Xiao Dan LIU,Zhen Gang XIE,Chu Jun LI. An Improved and Convenient Procedure for the Synthesis of Ozagrel[J]. Chinese Chemical Letters, 2006, 17(2): 180-182 |
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| Authors: | Chun GUO Xiao Dan LIU Zhen Gang XIE Chu Jun LI |
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| Abstract: | A novel approach to the synthesis of ozagrel is described. The target compound isconveniently prepared from the commercially available material, 1,1-carboxyldiimidazole (CDI)through the condensation and hydrolyzation. |
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| Keywords: | Ozagrel synthesis 1 1-carboxyldiimidazole. |
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