NaIO4/LiBr-mediated diastereoselective dihydroxylation of olefins: a catalytic approach to the Prevost-Woodward reaction |
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Authors: | Emmanuvel Lourdusamy Shaikh Tanveer Mahammad Ali Sudalai Arumugam |
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Affiliation: | Chemical Engineering and Process Development Division, National Chemical Laboratory, Pune, India. |
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Abstract: | [reaction: see text] LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO(4) (30 mol %) or PhI(OAc)(2) (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields. |
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