Total synthesis of (+/-)-paeonilide |
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| Authors: | Wang Chenying Liu Jikai Ji Yanhua Zhao Jingfeng Li Liang Zhang Hongbin |
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| Institution: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, People's Republic of China. |
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| Abstract: | The total synthesis of paeonilide, a natural anti-PAF (platelet-activating factor) new skeleton monoterpenoid with an IC(50) value of 8 microg/mL, was achieved in 16 steps with 15% overall yield from commercially available 2-hydroxy-4-methylacetophenone. reaction: see text] |
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