Complete assignments of the 1H and 13C resonances of 40-epi-(N1-tetrazolyl)-rapamycin and revised 13C assignments for rapamycin |
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| Authors: | Pagano Thomas G |
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| Institution: | Abbott Laboratories, Global Pharmaceutical Research and Development Division, 100 Abbott Park Rd, Abbott Park, IL 60064-6114, USA. thomas.g.pagano@abbott.com |
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| Abstract: | Complete 1H and 13C assignments of 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578) in DMSO-d6 were made using 1H, 13C, DQCOSY, ROESY, TOCSY, HSQC and HMBC spectra. Comparing the assignments with those of rapamycin showed that in the published 13C assignments of rapamycin in DMSO-d6 the shifts for C-12 and C-42 have been interchanged, as well as the shifts for C-1 and C-8. |
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