Construction of a pH-responsive drug delivery platform based on the hybrid of mesoporous silica and chitosan |
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Authors: | Keliang Zhang Jun Gao Shangji Li Ting Ma Linhong Deng Yong Kong |
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Institution: | 1. Department of Science and Education, Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou 213000, China;2. Department of Orthopedics, Changzhou Municipal Hospital of Traditional Chinese Medicine, Changzhou 213003, China;3. Jiangsu Key Laboratory of Advanced Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China |
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Abstract: | Mesoporous silica nanoparticles (MSN) have been widely used for drug delivery due to their large specific surface area and excellent biocompatibility. However, the mesoporous structure of MSN would lead to the inevitable “premature release” of the drugs, and therefore the modification of MSN for controlled delivery seems to be a necessary step. Herein, chitosan (CS) was used for the surface functionalization of MSN via amidation reaction, and the introduced CS could function as a “gatekeeper” and the drug of methotrexate (MTX) might be encapsulated in the mesopores of MSN. As a result, the “premature release” of the encapsulated MTX could be effectively circumvented with the aid of the CS cap. More importantly, the drug delivery from the hybrid of MSN and CS (MSN/CS) can be endowed with pH-sensitivity by the introduction of CS because the amide bonding between CS and MSN is highly pH-sensitive. The cumulative release of MTX from the MSN/CS is more pronounced at pH 5.0 (80.86%) than those at pH 6.8 (40.46%) and pH 7.4 (18.25%). |
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Keywords: | Mesoporous silica Chitosan pH-sensitivity Drug delivery Methotrexate |
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