| Synthesis of Novel Monophosphoramidite Ligands Derived from L-Proline for Rh-catalyzed Asymmetric Hydrogenation of α-Dehydroamino Acid Esters |
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| 作者姓名： | Qing Heng ZENG Xiang Ping HU Xin Miao LIANG Zhuo ZHENG |
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| 作者单位： | [1]Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 [2]Graduate School of Chinese Academy of Sciences, Beijing 100039 |
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| 摘 要： | Two novel monophosphoramidites were synthesized through a five-step transformation from commercially available L-proline. In the Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acid derivatives, ligand （Sc,Rα）-1b showed good enantioselectivity and up to 91% e.e. was obtained.
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| 关 键 词： | 脯氨酸 催化加氢 氨基酸 配合基 合成方法 |
| 收稿时间： | 2005-01-14 |
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