Dual electrochemical microsensor for simultaneous measurements of nitric oxide and oxygen: Fabrication and characterization |
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| Authors: | Sarah S. Park Clarissa E. Tatum Youngmi Lee |
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| Affiliation: | aDepartment of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea;bDepartment of Chemistry, The University of Tennessee, Knoxville, TN 37996-1600, USA |
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| Abstract: | A planar-type amperometric dual microsensor was developed for the simultaneous measurement of the nitric oxide (NO) and oxygen (O2) concentrations. The sensor (overall diameter =  500 μm) consisted of a dual working electrode (WE) containing two platinized platinum microdisks (25 μm diameter, WE1, WE2, distance between two disks > 330 μm) and a Ag/AgCl wire reference electrode covered with an expanded poly(tetrafluoroethylene) gas-permeable membrane. The differentiation and concurrent measurements of NO and O2 were obtained successfully using two sensing WEs with different applied potentials (+0.75 V for WE1 and −0.4 V for WE2). Cross-talk between WE1 and WE2 was eliminated with an optimized internal solution composition. Linear dynamic range, selectivity, sensitivity, detection limit (<5 nM for NO; <500 nM for O2), and stability (>50 h) were evaluated. |
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| Keywords: | Dual microsensor Nitric oxide Oxygen Amperometry Cross-talk |
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