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Cytotoxicity evaluation of coumarin derivatives containing 4-bromophenyl or anthracene moieties |
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| Authors: | Hui Zhang Ming Zhao Tianzhi Yu Yuling Zhao Duowang Fan Shidong Zhang |
| Institution: | 1. Key Laboratory of Opto-Electronic Technology and Intelligent Control (Ministry of Education), Lanzhou Jiaotong University, Lanzhou, 730070, China 2. School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, China 3. Lanzhou Institute of Husbandry and Pharmaceutical Science of Chinese Academy of Agricultural Science, Lanzhou, 730070, China |
| Abstract: | The cytotoxic properties of four synthesized coumarin derivatives containing 4-bromophenyl or anthracene moieties against the human hepatocellular carcinoma cell lines (HepG-2) were investigated in vitro by use of the sulforhodamine B (SRB) assay. The four coumarin derivatives are 3-(4-bromophenyl)-benzo5,6]coumarin (1a), 3-(4-bromophenyl)-7-(N,N-diethylamino)coumarin (1b), 3-(4-(anthracen-10-yl)phenyl)-benzo5,6]coumarin (2a), and 3-(4-(anthracen-10-yl)phenyl)-7-(N,N-diethylamino)coumarin (2b). The preliminary results indicate that 1a, 2a, and 2b have significant cytotoxicity against HepG-2 whereas 1b has a growth-promotion effect. |
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