Microwave-assisted synthesis and biological activity of new Schiff bases derived from dimers of 4-amino-3-[3-(1-benzyl)indole]-5-thiomethyl-1,2,4-triazole |
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Authors: | Yongle Peng Zhigang Zhao Xingli Liu Guohua Li |
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Affiliation: | 1. College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China
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Abstract: | An expeditious method with microwave irradiation has been developed for synthesis of novel Schiff bases from dimers of 4-amino-3-[3-(1-benzyl)indole]-5-thiomethyl-1,2,4-triazole. Its distinct advantages are short reaction times and good conversion. The structures of these new Schiff bases were established by 1H NMR, IR, and mass spectroscopy, and elemental analysis. The antibacterial activity of ten novel Schiff bases against three bacterial strains was studied by the disk diffusion method. Preliminary results indicated that some of the compounds had strong antibacterial activity. |
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