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Synthesis and cytotoxicity study of pyrazoline derivatives of methoxy substituted naphthyl chalcones |
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| Authors: | K R Ethiraj P Nithya V Krishnakumar A Jesil Mathew F Nawaz Khan |
| Institution: | 1. Pharmaceutical Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632 014, Tamil Nadu, India 2. Chemistry Division, School of Advanced Sciences, VIT University - Chennai Campus, Chennai, 600 127, Tamil Nadu, India 3. Organic Chemistry Division, Organic and Medicinal Chemistry Research Laboratory, School of Advanced Sciences, VIT University, Vellore, 632 014, India 4. Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Udupi, Karnataka, India |
| Abstract: | 2-Acetyl naphthalene reacts with various methoxy substituted benzaldehyde in the presence of 10 % sodium hydroxide solution giving functionalized chalcones. The synthesized chalcones when further reacted with hydrazine hydrate in the presence of acetic acid afforded N-acetyl pyrazolines. All the synthesized products were confirmed by various spectral data such as FTIR, 1H NMR, 13C NMR, and HRMS studies. All the synthesized compounds were screened for cytotoxicity against various cell lines. |
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