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Prefrontal and anterior cingulate cortex abnormalities in Tourette Syndrome: evidence from voxel-based morphometry and magnetization transfer imaging |
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| Authors: | Kirsten R Müller-Vahl J?rn Kaufmann Julian Grosskreutz Reinhard Dengler Hinderk M Emrich and Thomas Peschel |
| Institution: | (1) Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany;(2) Department of Neurology, Hannover Medical School, Hannover, Germany;(3) Department of Neurology II, Center for Advanced Imaging (CAI), Otto-von-Guericke-University Magdeburg, Magdeburg, Germany;(4) Department of Neurology, University of Jena, Jena, German;(5) Center for Systems Neurosciences (ZSN), Hannover, Germany |
| Abstract: | BackgroundPathophysiological evidence suggests an involvement of fronto-striatal circuits in Tourette syndrome (TS). To identify TS related abnormalities in gray and white matter we used optimized voxel-based morphometry (VBM) and magnetization transfer imaging (MTI) which are more sensitive to tissue alterations than conventional MRI and provide a quantitative measure of macrostructural integrity. |
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