Laminin enhances the growth of human neural stem cells in defined culture media |
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| Authors: | Peter E Hall Justin D Lathia Maeve A Caldwell Charles ffrench-Constant |
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| Institution: | (1) Department of Pathology, University of Cambridge, Cambridge, UK;(2) Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK;(3) Laboratory of Neurosciences, National Institute on Aging, Baltimore, USA;(4) Laboratory for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK;(5) MRC Centre for Regenerative Medicine, Queen's Medical Research Institute, Edinburgh, UK |
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| Abstract: | Background Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such
as multiple sclerosis and Parkinson's disease. In order to realise this goal, protocols need to be developed that allow for
large quantities of hNSC to be cultured efficiently. As such, it is important to identify factors which enhance the growth
of hNSC. In vivo, stem cells reside in distinct microenvironments or niches that are responsible for the maintenance of stem cell populations.
A common feature of niches is the presence of the extracellular matrix molecule, laminin. Therefore, this study investigated
the effect of exogenous laminin on hNSC growth. |
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