| 基于多肽和温敏聚合物的光交联囊泡的制备及表征 |
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| 作者单位： | 1. Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, P. R. China;2. Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China |
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| 基金项目： | the National Natural Science Foundation of China(21374080);the National Natural Science Foundation of China(21674081);the National Natural Science Foundation of China(21611130175);Shanghai International Scientific Collaboration Fund, China(15230724500);Shanghai 1000 Talents Plan, and Fundamental Research Funds for the Central Universities, China(0500219211);Shanghai 1000 Talents Plan, and Fundamental Research Funds for the Central Universities, China(1500219107) |
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| 摘 要： |
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| 关 键 词： | 囊泡 多肽 胶囊 可逆加成断裂链转移聚合 N-羧基酸酐(NCA) |
| 收稿时间： | 2016-12-12 |
Synthesis and Characterization of Thermo-Responsive Polypeptide-Based Vesicles with Photo-Cross-Linked Membranes |
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| Authors: | Kang YUAN Xue ZHOU Jian-Zhong DU |
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| Institution: | 1. Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, P. R. China;2. Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China |
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| Abstract: | It is an important challenge to balance the degradability and stability of polymer vesicles. We report a thermo-responsive vesicle based on poly(N-isopropyl acrylamide-stat-7-(2-methacryloyloxyethoxy)-4-methylcoumarin)-b-(L-glutamic acid)] P (NIPAM45-stat-CMA5)-b-PGA42] diblock copolymer, which was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization and ring-opening polymerization (ROP). The membrane of the vesicle consists of thermo-responsive PNIPAM and photo-cross-linkable PCMA. The PGA chains in the vesicle coronas can colloidally stabilize the vesicles in water and can be postfunctionalized for further applications. Transmission electron microscopy and dynamic light scattering studies confirmed the formation of vesicles. Overall, we prepared a new functional thermo-responsive vesicle based on polypeptide copolymers that may be used as nanocarriers for the facile loading of a range of molecules in future. |
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| Keywords: | Vesicle Peptide Polymersome Reversible addition fragmentation chain transfer N-carboxyanhydride (NCA) |
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