Mebendazole complexes with various cyclodextrins: preparation and physicochemical characterization |
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Authors: | Malika Lahiani-Skiba Aude Coquard Fréderic Bounoure Philippe Vérité Philippe Arnaud Mohamed Skiba |
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Institution: | (1) Laboratoire de Pharmacie Galénique, ADEN 3234, UFR Médecine & Pharmacy, Rouen University, 22, Bd Gambetta, 76000 Rouen, France;(2) Laboratoire de Chimie Analytique, ADEN 3234, UFR Médecine & Pharmacy, Rouen University, 22, Bd Gambetta, 76000 Rouen, France;(3) In-Cyclo, ADEN 3234, UFR Médecine & Pharmacy, Rouen University, 22, Bd Gambetta, 76000 Rouen, France |
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Abstract: | Mebendazole is an antihelmintic drug, active against many intestinal parasites. Its systemic efficacy is limited by its poor
water solubility. The use of natural or derivatized cyclodextrins permeated to multiply notably its apparent solubility, especially
with permethyl β-cyclodextrine (PM β-CD) (multiplied by 4700). The inclusion complex formation between mebendazole and this
methylated β-cyclodextrin, was characterized by mass spectrometry, powder X-ray diffractometry and Fourier transform infrared
spectroscopy: mebendazole seemed to be included in permethyl β-cyclodextrin by its aromatic rings. To prepare inclusion complex
of mebendazole and PMβ-CD by solvent evaporation, acetone may be used and the ratio using lower amount of cyclodextrin (MBZ:CD,
1:2) should be used. |
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Keywords: | Mebendazole Cyclodextrins Inclusion complex Physicochemical characterization |
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