Microwave-Assisted Minutes Synthesis of Bioactive Phenylbutanoids Occurring in <Emphasis Type="Italic">Zingiber cassumunar</Emphasis> |
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Authors: | B P Joshi N P Singh A Sharma A K Sinha |
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Institution: | (1) Natural Plant Products Division, Institute of Himalayan Bioresource Technology, Palampur (H.P.), 176061, India |
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Abstract: | Microwave-assisted condensation of benzaldehyde (3a,b) with acetone in aqueous sodium hydroxide adsorbed on basic alumina provides phenylbutenone (4a–4b) in 68–71% yield within 4 min, which upon further reduction with sodium borohydride and basic alumina gives phenylbutenol
(5a,b) in 91–94% yield within 2 min. Dehydration of 5 with anhydrous copper (II) sulfate gives phenylbutadiene (1a,b), a metabolite of Zingiber cassumunar, within 3 min in 42–48% yield, respectively. All the steps involve environmental friendly solvents and reagents, mild reaction
conditions, and overall formation of product 1a,b from 3a,b in 34–38% yield within 9 min under microwave irradiation.
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Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 300–302, July–August, 2005. |
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Keywords: | microwave phenylbutanoids phenylbutadiene Zingiber cassumunar |
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