Designing N-heterocyclic carbenes: simultaneous enhancement of reactivity and enantioselectivity in the asymmetric hydroacylation of cyclopropenes |
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| Authors: | Liu Fan Bugaut Xavier Schedler Michael Fröhlich Roland Glorius Frank |
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| Affiliation: | Organisch‐Chemisches Institut, Westf?lische Wilhelms‐Universit?t Münster, Corrensstrasse 40, 48149 Münster (Germany) |
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| Abstract: | Faster, higher, stronger! The N-heterocyclic carbene (NHC) catalyzed diastereo- and enantioselective hydroacylation of cyclopropenes affords structurally valuable acylcyclopropanes. A new family of electron-rich, 2,6-dimethoxyphenyl-substituted NHCs induces excellent reactivity and enantioselectivity. Preliminary kinetic studies unambiguously demonstrated the superiority of this family of catalysts over known NHCs in this challenging transformation. |
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| Keywords: | cyclopropenes enantioselective catalysis hydroacylation N‐heterocyclic carbenes organocatalysis |
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