A novel software tool for copolymer characterization by coupling of liquid chromatography with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry |
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| Authors: | Weidner Steffen M Falkenhagen Jana Maltsev Sergey Sauerland Volker Rinken Marian |
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| Institution: | Federal Institute for Materials Research and Testing (BAM), Dept. I Analytical Chemistry, Reference Materials, Richard-Willstaetter-Strasse 11, D-12489 Berlin, Germany. steffen.weidner@bam.de |
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| Abstract: | The results of copolymer characterization by coupling of chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) techniques and subsequent calculation of copolymer composition using a novel software tool 'MassChrom2D' are presented. For high-resolution mass analysis copolymer samples were fractionated by means of liquid adsorption chromatography (LAC). These fractions were investigated off-line by MALDI-TOF MS. Various mono-n-butyl ethers of polyethylene oxide-polypropylene oxide copolymers (PEO-co-PPO) were investigated. As well as the copolymer composition presented in two-dimensional plots, the applied approach can give additional hints on specific structure-dependent separation conditions in chromatography. |
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